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Figure 3. Kinetics of Zn2+ inhibition and recovery are temperature sensitive. (A) Inhibition of ClC-0 by 10 μM Zn2+ at three different temperatures. (B) Inhibition of Shaker K+ channels by 20 mM TEA. The membrane potential was held at −80 mV and a 30-ms voltage pulse to +30 mV was given every second. Dotted lines in A and B represent zero-current level. (C) Comparison of the time constants of Zn2+ inhibition of ClC-0 (○ and ▵) with those of TEA inhibition of the Shaker K+ channel (• and ▴). Circles, time constants of current inhibition; triangles, time constants of current recovery (n = 4–5).

Image published in: Chen TY (1998)

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