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Figure 3. Effects of tyrosine kinase inhibitor and dominant-negative RAS antibody on IGF-1 effects on the serotonin response in Xenopus oocytes. Shown are peak Cl- currents in response to 5-HT after the indicated treatments. (A) Genistein, a tyrosine kinase inhibitor, blocks the inhibitory effect of IGF-1 on the 5-HT response. The data are presented as mean ± S.E.M. of 11-12 oocytes (*, P < 0.05). (B) RAS antibody, Y13-259, blocks the inhibitory effect of IGF-1 on the 5-HT response. The data are presented as mean ± S.E.M. of 6 oocytes (*, P < 0.05).

Image published in: Hurley JH et al. (2003)

Image downloaded from an Open Access article in PubMed Central. Copyright © 2003 Hurley et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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