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Figure 4. . Potency of diamine block depends on glutamate location. (A–D) Left, representative currents from voltage step protocols illustrating currents in the absence of diamine/polyamine (Control), and rectification induced by spermine and diamines of different alkyl chain length in glutamate mutant channels (left). Scale bar represents 200 ms and 0.5 nA (A and B) or 2 nA (C and D). Diamines and polyamines were applied at 100 μM, unless otherwise indicated. Right, relative conductance (Grel)–voltage relationships, obtained as in Fig. 3, were fit with single Boltzmann functions, with an offset for nonblocked current (see Fig. 5). Image published in: Kurata HT et al. (2004) Copyright © 2004, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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