XB-IMG-122305
Xenbase Image ID: 122305
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Figure 13. . History-dependent, tail current kinetics. A similar development in (A) HCN1 channels and (B) spHCN channels, of a delay in the tail currents at +50 mV in response to the increasing length of the activation pulse. Pulse potential: −100 mV (A) and −80 mV (B). Extracellular K concentration: 10 mM (A) and 100 mM (B). (C) Normalized tail current amplitudes from A, showing the slowing of the tail kinetics. Arrow indicates increasing prepulse lengths. (D) Time course of the development of the delay, measured as the tail current amplitude, 10 ms after the onset of the tail potential (arrow in C), fitted with a single exponential with τ = 250 ms. (E) Tail currents at −80 mV for HCN1 after increasing prepulses to −160 mV. The prepulse length is increased with 50 ms between each trace. Arrow indicates increasing prepulse lengths. (F) Normalized currents, first and last trace, from E. Arrow indicates increasing prepulse lengths. τ = 98.3 ± 5.2 ms (n = 3) for the first trace and τ = 211 ± 16 ms (n = 3) for the last trace. Image published in: Männikkö R et al. (2005) Copyright © 2005, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |