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Fig. 4. A model of nuclear actin-mediated transcriptional reprogramming of occluded genes. Expression of occluded genes, such as Oct4, is repressed by chromatin-based mechanisms. During transcriptional reprogramming, repressors and/or repressive marks that restrict access of transcriptional activators to chromatin may be removed with the help of nuclear actin. In addition, actin-containing chromatin remodeling complexes like the BAF complex can accelerate chromatin opening. Clearing chromatin-based repression enables transcriptional activators and Pol II to have access to promoters of occluded genes. Pol II-mediated transcription is also enhanced by nuclear actin

Image published in: Miyamoto K and Gurdon JB (2013)

Image downloaded from an Open Access article in PubMed Central. © The Author(s) 2012

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