Xenbase Image ID: 120928

Figure 2. Aligned sequences of the M2 segments of mouse-muscle ACh receptor subunits. The numbering is that of the α subunit. The predicted membrane-spanning segments correspond to αM243 to αV261. The intracellular (IN) and extracellular (EX) ends are indicated. *Residues are aligned with residues in the ACh receptor from Torpedo electric tissue that were labeled by noncompetitive inhibitor derivatives. Mutations of the boxed-in residues affected channel block by QX-222. Cysteines substituted for the residues in bold italics are exposed in the channel in the presence of ACh (tested only in α and β). See text for references. Image published in: Pascual JM and Karlin A (1998) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

Return to previous page