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Figure 1. Equilibrium models of coupling between voltage sensors and gating. (A) Standard allosteric model for coupling of four voltage sensors to simple channel opening. (B) Simplified version of A, with equilibrium constants summarized for fully activated (A) and deactivated (D) voltage sensors and open (O) and closed (C) channels. The diagram is heuristic and does not indicate a direct connection between C0 and C4 or between O0 and O4; the overall equilibrium constants shown between these extreme states are simply equal to the product of the intervening equilibrium constants. (C) Two approaches to estimating the coupling constant θ. Image published in: Ryu S and Yellen G (2012) © 2012 Ryu and Yellen. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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