XB-IMG-129356
Xenbase Image ID: 129356
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Figure 5. Slowed Closing predicts steady state inactivation midpoints for AKv1(E2x) series mutants.A) Best fit to AKv1(E2x) channel data is shown in black. Prediction for the steady state inactivation midpoints based on AKv1(Δ2-57) activation gating shown in orange. AKv1(E2x) data are well fit with a linear model (r = −0.99); however, the y-intercept is more negative than expected and the slope is flatter than predicted from AKv1(Δ2-57) activation. B) Predicted value for ks from the fit is smaller than the activation curve ks, and similar to ks values measured from the inactivation curves, as expected from the more complex multi-step activation of the real channel. Image published in: Pfaffinger PJ (2013) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license Larger Image Printer Friendly View |