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Figure 4. Blockade of charge movements in D444S-EAAC1 by succinate and acidic amino acids. The charge moved was calculated from the isolated transient current–time integrals as described under Materials and Methods. The fraction of transient currents blocked at each concentration of the indicated compound was normalized to the transient currents isolated by saturating (10 mM) concentrations of L-glutamate (circles), L-aspartate (triangles), D-aspartate (diamonds), and succinate (squares) and is shown in A. The current–time integrals of the transients ranged from 1.0 to 2.8 nC. Data shown are mean ± SEM of four to six oocytes. The currents blocked by 10 mM D- and L-aspartate in the same oocyte are shown in B and C, respectively.

Image published in: Teichman S and Kanner BI (2007)

Copyright © 2007, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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