XB-IMG-123127
Xenbase Image ID: 123127
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FIGURE 6. Effect of MTS compounds on ATP responses of P2X4 cysteine mutants. A, trace data representative of currents observed on the addition of MTSEA (1 mm). ATP application (EC50 concentration) is indicated by the bar. MTSEA reagent was bath applied 5 min prior to U-tube ATP coapplication with MTSEA. Traces are shown in response to ATP for a given oocyte before and during the application of MTSEA. B, graph representing the effect of MTSEA on the P2X4 WT and mutant receptors (n = 3â8). C, trace data representative of currents observed on the addition of MTSES (1 mm). ATP application (EC50 concentration) is indicated by the bar. MTSES reagent was applied in a similar manner to MTSEA. Traces are shown in response to ATP for a given oocyte before and during the application of MTSES. D, graph representing the effect of MTSES on the P2X4 WT and mutant receptors (n = 3â6). *, p < 0.05; **, p < 0.01; ***, p < 0.001. Image published in: Roberts JA et al. (2008) Copyright © 2008, The American Society for Biochemistry and Molecular Biology, Inc. Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View |