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Figure 5. Hyperpolarization cannot turn off currents activated by Ca2+. Excised patches were exposed to 500 nM Ca2+ (A and B) or 1 μM Ca2+ (C and D). The membrane potential was held at various values between −200 and 0 mV. The instantaneous currents at +120 mV were measured to determine the conductance activated at the preceding voltage. At both [Ca2+], hyperpolarization to −200 mV was not able to inactivate the Ca2+-activated current. Only selected traces are shown in A and C for clarity.

Image published in: Kuruma A and Hartzell HC (2000)

© 2000 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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