XB-IMG-124420
Xenbase Image ID: 124420
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Figure 5. Effect of (S)-2 on the activation kinetics of Kv7.2 and Kv7.4.For determination of activation kinetics, current traces recorded during 5 s voltage steps from –80 mV to potentials between –40 and +40 mV for Kv7.2 in the absence and presence of (S)-2 were fitted to a double exponential function and the time constants τfast (A) and τslow (B) obtained were plotted against the step potential. For Kv7.4 current traces recorded during 5 s voltage steps to potentials between –20 and +60 mV were fitted to a single exponential function and τ is plotted against the step potential (C). Asterisks indicate statistical significant difference between absence and presence of (S)-2 determined by two-way ANOVA followed by Bonferroni post-test. * P<0.05, ** P<0.01 and *** P<0.001. Bars represent S.E.M. and n = 8-13. Image published in: Blom SM et al. (2009) Blom et al. Creative Commons Attribution license Larger Image Printer Friendly View |