Xenbase Image ID: 195563

Fig. 3. Cell lineage relationships in the mammalian embryo and their regulation by the BMP and Activin/nodal signaling pathways and the Mixl1 transcription factor. The colour scheme reflects the graded BMP/nodal signalling along the primitive streak that induces and patterns mesoderm and endoderm. Activation of BMP or Activin receptors leads to phopshorylation and nuclear translocation of heterodimeric Smad proteins that form activating complexes on the Mixl1 promoter in combination with proteins including FoxH1 or FoxH3. The inclusion of Eomes in these complexes is not yet confirmed. Image published in: Pereira LA et al. (2012) Copyright © 2012. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page