XB-IMG-122315
Xenbase Image ID: 122315
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Figure 2. . Single-channel conductance of the N240R mutation. (A) Alignment of the amino acid sequences of the rat Kir channel family, showing sequence differences at positions N240. (B) Inward current traces for the mutant N240R measured in the cell-attached configuration with cell potentials of −40 to −140 mV. Dotted lines indicate the closed state and upward deflections indicate channel openings. (C) I–V relationships for N240R, N240K, and N240E, with data from ROMK2 and C13 shown for comparison. Data represent means ± SEM for at least three different patches. A minimum of 15 transitions at each voltage were measured to obtain values for each patch. The slope conductances measured between −60 and −140 mV were ROMK2, 43 pS; C13, 31 pS; and N240R, 31 pS. Image published in: Zhang YY et al. (2004) Copyright © 2004, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |