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Figure 11. . Voltage ramps. (A) Conductance of spHCN channels during voltage ramps from −10 mV to −100 mV, and back to −10 mV, using different ramp speeds. 100-K bath solution. The conductance was normalized to 1 at −100 mV. (B) Conductance of Shaker channels during voltage ramps from −80 mV to +20 mV, and back to −80 mV, using different ramp speeds. The conductance was normalized to 1 at +20 mV. 1-K bath solution. Note that with a slower ramp speed, voltage hysteresis decreases in Shaker channels, whereas it increases in spHCN channels. With slower voltage ramps, the two limbs in the G(V) curve approach each other in Kv channels, but in HCN channels, the two limbs are well separated even for slow ramps. (C–F) Computer simulations of voltage-ramp currents for the models in Fig. 5. The ramp speed is 125, 250, 500, 1,000, and 2,000 mV/s (from periphery to center). (G and H) Hysteresis measured as the voltage separation between the upward and downward limbs at 50% relative conductance (relative to the conductance at −100 mV).

Image published in: Männikkö R et al. (2005)

Copyright © 2005, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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