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Figure 4. The centrosome could be the F-molecule orienting the 3 axes at fertilization. (A) The unfertilized egg, seen from the animal pole, is radially symmetric about the animal-vegetal axis but contains a chiral actin cytoskeleton.47 (B) At fertilization, the sperm entry point produces the first “point” around the circumference that is different from any other. The direction of the actin cytoskeleton at this point establishes a linear LR axis—a convergence of the 3 axes that could enable the MTOC to be uniquely oriented and thus establish directional asymmetries in the microtubule cytoskeleton that would underlie asymmetric transport of intracellular components.70 Image published in: Vandenberg LN et al. (2013) Copyright © 2013 Landes Bioscience. Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View

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