XB-IMG-124095
Xenbase Image ID: 124095
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Fig. 1. Schematic representation of HCN1-R. The six transmembrane segments of a monomeric subunit of the HCN1-R are shown. Six endogenous cysteine residues are removed together with the truncation of the âCOOH terminus. Five of the six remaining cysteine residues are replaced by a serine, threonine, or isoleucine substitution. C303 in the S5 segment is left in the final HCN1-R construct because of lack of functional current upon mutations. Their approximate locations, as well as the GYG signature motif, are highlighted as shown. The eight amino acid residues in the P-S6 motif of the final HCN1-R construct are individually replaced by cysteine and named accordingly Image published in: Siu CW et al. (2009) Image downloaded from an Open Access article in PubMed Central. © The Author(s) 2009 Larger Image Printer Friendly View |