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XB-IMG-129738

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Figure 5. Diamide specifically react with cysteines and produces the same effects as tBHP with similar concentration dependence.A. Outward currents expressed by Kv4.2+KChIP3a+DPP6a channels in response to 1-sec step depolarizations from −100 mV holding potential to +60 mV in 20 mV increments. B. Overlapped 500-ms-long current traces at +60 mV before and after diamide exposure. Post-treatment trace was also scaled to that of pre-treatment trace to illustrate the dramatic slowing of inactivation. C. Relative change in peak current amplitude at +60 mV in response to oxidation by diamide and reduction by DTT. With diamide, n = 6; DTT washout, n = 3. D. Concentration dependence of oxidative regulation by diamide, as measured by normalized peak current amplitude. The fitted trace is the best fit using a first-order Boltzmann function.

Image published in: Jerng HH and Pfaffinger PJ (2014)

Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license

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