XB-IMG-122699
Xenbase Image ID: 122699
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Figure 2. Stabilization of Kir2.1 channel activity by long diamines. Ramp pulse–elicited current traces showing that spontaneous rundown after patch excision was prevented by (A) spermine (Spm), (B) diamine 12 (DA12), and (C) diamine 10 (DA10), but not (D) putrescine (Put, DA4), all at 100 μM concentration, holding potential between ramps 0 mV. (E). Normalized current (I/I0) 5 min after excising the patch into control solution (ctl), or solution containing 100 μM Spm, DA12, DA10, Put, or 10 μM PIP2. I0 represents current level at −100 mV before rundown. Numbers of patches are indicated in parentheses above each bar. Data are shown and mean ± SEM. **, P < 0.05 compared with ctl. Image published in: Xie LH et al. (2005) Copyright © 2005, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |