Xenbase Image ID: 126216

Fig. (1). Inhibitory effects of PCP on GIRK channels expressed in Xenopus oocytes. (A) Top, in an oocyte injected with GIRK1 and GIRK2 mRNA, current responses to 10 µM and 100 µM PCP and to 3 mM Ba2+, a Kir channel blocker. Middle, in an oocyte injected with Kir1.1 mRNA, current responses to 100 µM PCP and to 3 mM Ba2+. Bottom, in an uninjected oocyte, no significant current responses to 100 µM PCP or 3 mM Ba2+. Asterisks show the zero current level. Bars show the duration of application. (B) Concentration-dependent inhibition of GIRK channels by PCP. The magnitudes of inhibition of GIRK currents by PCP were compared with the current components sensitive to 3 mM Ba2+. Image published in: Kobayashi T et al. (2011) ©2011 Bentham Science Publishers Ltd. Creative Commons Attribution license Larger Image Printer Friendly View

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