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Xenbase Image ID: 122349

Figure 6. . Conductance–voltage relations for HCN2 channels. (A–F) Conductance versus voltage plots for wild-type HCN2 (A), K472E (B), E502K (C), D542K (D), K472E+E502K (E), and K472E+D542K (F). Each plot indicates GV curves, obtained from normalized tail currents at −40 mV, in the absence (black) and presence of saturating cAMP (red). The data are fit with a Boltzmann relation. Diagrams on the left and the right show attractive electrostatic interactions by solid lines and repulsive electrostatic interactions by a dotted line with wild-type residues as open symbols and mutant residues as shaded symbols.

Image published in: Craven KB and Zagotta WN (2004)

Copyright © 2004, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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