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Figure 12. UV effects on currents through CNG channel pore tryptophan mutants activated by different ligands. (A and B) UV dose–response relations for OLF/W332Y (A) and OLF/W332H (B) mutant channels activated by saturating cAMP (1 mM, solid symbols) or saturating cGMP (1 mM, open symbols). Collected results from three experiments in cAMP and eight experiments in cGMP for OLF/W332Y channels, and three experiments in cAMP and five experiments in cGMP for OLF/W332H channels. Different symbols represent separate experiments. Results from separate experiments on each channel/ligand pair were combined as described in Fig. 3 A. Continuous curves are fits to the combined results for each channel activated by cGMP or cAMP using . D1/2 values and slope factors from the fits are given in Table . Channels were irradiated with 280 nm UV in the absence of ligand.

Image published in: Middendorf TR and Aldrich RW (2000)

© 2000 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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