Xenbase Image ID: 120123

Figure 4. Effect of heterologous Gαs overexpression on basal and agonist-induced GIRK currents. (A) Statistics of effect of Gαs overexpression on basal current, normalized to basal IHK current of control (no Gαs overexpressed). Calculated average values ± SEM from two different batches of oocytes are shown (three to five oocytes per batch). Individual experiments were performed either in the absence (white bars) or after preincubation (gray bars) of oocytes in 50 μmol/liter H89. (# and ##) Mean value deviates significantly (P < 0.05 and 0.01) from the corresponding basal current (same amount of Gαs cRNA injected), but without H89 preincubation. (*, **, and ***) Mean value deviates significantly (P < 0.05, 0.01, and 0.001) from the basal current without Gα s overexpression. (B) Same as in A, but agonist-induced GIRK currents are normalized to IACh of control (no Gαs overexpressed). Image published in: Müllner C et al. (2000) © 2000 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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