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Figure 10. Single-channel conductances of WT, 1-432+433-1480, 1-633+634-1480, FlagWT, Flag3-432+433-1480, and Flag3-633+634-1480 channels in symmetrical 140 mM Cl−. (A and B) Segments of representative CFTR channel current records, illustrated for WT and 1-432+433-1480, at holding potentials of −80, −40, 0, +40, and +80 mV, were used to create amplitude histograms, fitted by sums of Gaussians (right). The distances between adjacent peaks, plotted against potential gave linear I-V plots. (C) Fitted slopes gave conductances of 6.8 ± 0.3 (WT), 7.1 ± 0.2 (1-432+433-1480), 6.3 ± 0.2 (1-633+634-1480), 6.6 ± 0.3 (Flag-WT), 7.0 ± 0.2 (Flag3-432+433-1480), and 7.0 ± 0.1 (Flag3-633+634-1480), none of which differed significantly from WT at P < 0.1.

Image published in: Chan KW et al. (2000)

© 2000 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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