XB-IMG-127824
Xenbase Image ID: 127824
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Figure 8. Iinst and Ih flow through the ciHCNb pore in approximately the same proportion.A. Current traces elicited by a hyperpolarization of the membrane potential from a holding potential of −10 mV to −70 mV before (black trace) or after (gray trace) a 15 min incubation with ZD7288. The complete voltage protocol is shown below the current traces. The dotted line represents the zero current level. B. Bar graph of Iinst and Ih before (black bars) and after (gray bars) 15 minute incubation with ZD7288, as carried out in ‘A’. * indicates a significant block of the current component by this agent (p<0.05 in a two-tailed paired t-test). C. Plot of ZD7288-sensitive Iinst versus Ih. Black line represents a linear correlation, which was a significant (r = 0.9, p<0.05). D. Bar graph showing the ratio of Iinst over total current (Iinst+Ih) that is blocked by Cs+ or ZD7288; this ratio represents the proportion of blocked current that is due to block of Iinst. An example of the Cs+ data used for this figure is shown in Figure 2. In ‘B’ and ‘D’, values represent mean ± s.e.m and the numbers in brackets are the numbers of oocytes used. The ZD7288 data in ‘B’, ‘C’ and ‘D’ come from the same 9 oocytes. Image published in: Jackson HA et al. (2012) Image reproduced on Xenbase with permission of the publisher and the copyright holder. Creative Commons Attribution license Larger Image Printer Friendly View |