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Figure 5. UV effects on currents through different CNG channels. (A) UV dose–response relations for RET and OLF channels activated by saturating (1 mM) cGMP. Fraction of current remaining is plotted as a function of the logarithm of the photon dose. Collected results from 10 experiments on RET channels (open symbols) and 7 experiments on OLF channels (solid symbols). Different symbols indicate separate experiments. (B) Same as in A, except results for each type of channel were shifted along the abscissa as in Fig. 3 A. Continuous curves are fits to the pooled results using of the text. D1/2 values and slope factors obtained from the fits are given in Table . Patches were irradiated with 280 nm UV in the absence of cGMP. Image published in: Middendorf TR and Aldrich RW (2000) © 2000 The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View

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