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Figure 3. Block by divalent cations. (A) Macroscopic I-V curve of an outside-out patch coexpressing MEC-4d/10d, MEC-2, and MEC-6 exposed to varying Ca2+ concentrations. (B) Dose–response curves for blockade by Ca2+ and Mg2+ at −100 mV. The smooth curve is fit to the average values assuming a Hill coefficient of 1: \documentclass[10pt]{article} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{pmc} \usepackage[Euler]{upgreek} \pagestyle{empty} \oddsidemargin -1.0in \begin{document} \begin{equation*}I=I_{{\mathrm{max}}}(1+[X^{2+}]/K_{i}')^{-1}\end{equation*}\end{document}. Measured Ki' was 12.9 mM for Ca2+, 7.0 mM for Mg2+. (C) Apparent Ca2+ inhibition constant, Ki' as a function of auxiliary subunits. Vhold = −60 mV. (D) Voltage dependence and variation of block affinity. Each line represents a single patch, with Ki' measured at −60 and −100 mV.

Image published in: Brown AL et al. (2008)

© 2008 Brown et al. Creative Commons Attribution-NonCommercial-ShareAlike license

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