XB-IMG-120290
Xenbase Image ID: 120290
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Figure 8. . Larger state-dependent modification of T249C at more hyperpolarized potentials. Currents before (A), during (B), and after (C) the application of 10 mM extracellular MTSET applied at â130 mV. Currents during (D) and after (E) the application of 10 mM extracellular MTSET applied at 0 mV on the same oocyte as in A to C. In A, C, and E, the voltage steps are in â10-mV increments from 0 to â140 mV. In B and D, the voltage was held at 0 mV and then stepped to â120 mV for the test pulse, followed by a step to +50 mV for tail currents. The holding potential was 0 mV. MTSET was applied for 5 s between each episode. (F) Currents measured at the arrow in D as a function of cumulative exposure to MTSET. The modification time course for extracellular application of MTSET at 0 mV (âª) and at â130 mV (â¡). The bold lines are an exponential fit to the data (for â130 mV, the I4 was constrained to the value found for the fit at 0 mV). Ï = 3.5 M*s for â130 mV, and Ï = 0.0727 M*s for 0 mV. Similar results were seen in four oocytes. Image published in: Vemana S et al. (2004) Copyright © 2004, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license Larger Image Printer Friendly View |