XB-IMG-123946
Xenbase Image ID: 123946
![]() |
Figure 2. HEPES reduces feedback-mediated responses in the cone/horizontal cell network in the isolated retina of goldfish.A, Feedback responses elicited by a 500 ms full-field (3000 µm) stimulus (I = 0 log) delivered in the presence of a 20 µm spot of light (I = 0 log) centered on a cone voltage-clamped at −45 mV. Current responses are shown in control (left), in the presence of 20 mM HEPES (middle), and after washout (right). HEPES reduces the amplitude of the feedback-mediated responses. B, Responses of a monophasic horizontal cell to 550 nm light (I = 1 log) in control (left), and after application of 20 mM HEPES (right). HEPES hyperpolarizes horizontal cells and strongly reduces the light-induced hyperpolarization and the feedback-induced roll-back response (arrow). C, Responses of a biphasic horizontal cell to light of 550 nm (I = 1 log) and 650 nm (I = 1 log) in control (left), after application of 20 mM HEPES (middle), and after washout (right). HEPES reduces the feedback-induced depolarizing response due to deep red light stimulation (arrows). Image published in: Fahrenfort I et al. (2009) Image downloaded from an Open Access article in PubMed Central. This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Larger Image Printer Friendly View |