XB-IMG-128556
Xenbase Image ID: 128556
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Figure 6. KV7.2/KV7.3_P574 complexes still target to the AIS of cultured hippocampal neurons. Confocal images of cultured rat hippocampal neurons (10 DIV) expressing KV7.3 WT or KV7.3_P574S (A) and co-transfected with KV7.2 (B). (A) KV7.3 is primarily intracellularly expressed when expressed on its own. No significant KV7.3 expression is observed at the AIS. (B) When co-expressing KV7.3 with KV7.2, both channel subunits are observed at the AIS. KV7.3_P574S displays the same localization characteristics. White arrowhead points to the location of the AIS. Ankyrin-G: marker of the axon initial segment, MAP2: marker of the somatodendritic region of neurons. Scale bars 50 and 20 μm, respectively. Image published in: Gilling M et al. (2013) Copyright © 2013 Gilling, Rasmussen, Calloe, Sequeira, Baretto, Oliveira, Almeida, Lauritsen, Ullmann, Boonen, Brondum-Nielsen, Kalscheuer, Tümer, Vicente, Schmitt and Tommerup. Creative Commons Attribution license Larger Image Printer Friendly View |