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Figure 3. The tail of C10-TEA is a major contributor to the binding affinity to CNG channels. Leak-subtracted currents from five consecutive traces in the presence of 1 mM cGMP to a voltage step of +80 mV, from a holding potential of 0 mV. All traces were obtained from the same inside-out patch. The first trace from the left was acquired in the absence of any blocker, the second in the presence of 50 μM C10-TEA, the third with 50 μM C10-TMA, the fourth with 5 mM TEA, and finally the experiment was bracketed with control conditions. Between traces, the patch was perfused with a solution devoid of cGMP and blocker for at least 30 s. Leak currents were acquired during these periods and they showed no changes throughout the experiment.

Image published in: Contreras JE and Holmgren M (2006)

Copyright © 2006, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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