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Figure 2. . Gating current characteristics of the wild type rat skeletal muscle sodium channel. (A) Gating currents of the wild type sodium channel were elicited by pulsing to −50, −30, −10, and 30 mV after 400 ms prepulse to −130 mV. The recorded traces were obtained by using a P/4 protocol at a subtracting holding potential of 50 mV. The arrowheads separate the fast and the slow component of the gating currents at potentials −50 and −30 mV. (B) Time constants of gating, activation, and inactivation. The data was obtained by fitting the decay phase of the gating current to the equation: A*exp(−t/τ1) + B*exp(−t/τ2). The slow gating component, τq(s), is shown with squares and the fast gating component, τq(f), with circles. The filled triangles correspond to inactivation time constants, τinact, obtained by fitting ionic currents. The activation time constants, (τact) filled circle, were obtained by fitting the ionic currents using a simplified version of the model proposed by Vandenberg and Bezanilla (1991).

Image published in: Chanda B and Bezanilla F (2002)

Copyright © 2002, The Rockefeller University Press. Creative Commons Attribution-NonCommercial-ShareAlike license

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