Xenbase Image ID: 192052

Figure 1. Stickers-and-spacers framework that can be used to describe Velo1PLD. (A) The stickers-and-spacers framework subdivides biomolecules into sticker regions and spacer regions, whereby stickers contribute attractive interactions that drive phase transitions through multivalent interactions. (B) The Velo1 sequence architecture contains an N-terminal prion-like domain (Velo1PLD) and four fragments (F1–F4) as originally defined by Böke et al.39 The Velo1PLD sequence is shown explicitly with aromatic residues colored orange and all other residues colored black. (C) Questions of interest in this study are how sticker clustering (left) and spacer-related interactions (right) can alter the formation and equilibrium state of condensates formed by PLDs. Image published in: Holehouse AS et al. (2021) Image downloaded from an Open Access article in PubMed Central. © 2021 The Authors. Published by American Chemical Society Larger Image Printer Friendly View

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