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DOID:0050120 - hemophagocytic lymphohistiocytosis
Disease Ontology Definition:A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.
Synonyms: HPS, Hemophagocytic syndrome, haemophagocytic syndrome,
Xenbase Genes
:
stxbp2,
stx11,
unc13d,
prf1
| MONDO:0015540 - hemophagocytic syndrome |
Other Model Organisms: AGR, MGI, ZFIN, FlyBase, WormBase, RGD
Ontology Viewers: Disease Ontology, EMBL-EBI, OLSVis tree view, Ontobee
Parent(s):
lymphatic system disease (is_a)