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XB-PHENO-16448

Xla. Wt + pax6 CRISPR, Viet J et al. (2020)

Experiment + Assay: Xla. Wt + pax6 CRISPR + NF41-NF42 (stained tissue microscopy)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR pax6 pax6.L
pax6.S
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
stained tissue microscopy NF stage 41 to NF stage 42  
Anatomical Phenotypes: absent lens, absent retinal ganglion cell layer, absent retinal outer nuclear layer, decreased size of the photoreceptor layer, decreased size of the retinal inner nuclear layer, decreased size of the retinal pigmented epithelium
Source: Fig. 2. E, row3
Article: XB-ART-56586, PubMed