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XB-PHENO-22626

Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + B/B Homodimerizer, Shifley ET et al. (2012)

Experiment + Assay: Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + B/B Homodimerizer + NF37/38 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Mmu.fgfr1del-Mmu.fkbp1adel) fgfr1.L
fgfr1.S
 NF stage 3 (4-cell) vegetal blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 37 and 38  
Expression Phenotypes (8):
increased amount hhex.L expression in liver primordium
increased amount nkx2-1.L expression in lung bud
mislocalised nkx2-1.L expression in lung bud
mislocalised nr1h5.L expression in liver primordium
increased amount nr1h5.L expression in liver primordium
decreased amount pdx1.L expression in pancreas
decreased amount ptf1a.S expression in pancreas
decreased amount spry2.L expression in eye
Source: Fig 3
Article: XB-ART-45962, PubMed