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XB-PHENO-24150

Xla Wt + rab11a CRISPR, Nasr T et al. (2019)

Experiment + Assay: Xla Wt + rab11a CRISPR + NF44 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rab11a (Xla) rab11a.S
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 44  
Anatomical Phenotypes: abnormal development of transient tracheoesophageal septum, abnormal tracheoesophageal fold morphology, decreased size of the trachea
Human Disease Associations: esophageal atresia/tracheoesophageal fistula
Source: Fig.2.I, J
Article: XB-ART-56553, PubMed