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XB-PHENO-24215

Xla Wt + Hsa.DSPdel, Bharathan NK and Dickinson AJG (2019)

Experiment + Assay: Xla Wt + Hsa.DSPdel + NF29/30-31 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Hsa.DSPdel) dsp (Xla)
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 29 and 30 to NF stage 31 Krt5.2 Ab1
immunohistochemistry NF stage 29 and 30 to NF stage 31 Ctnnb1 Ab12
Expression Phenotypes (1):
decreased amount krt61L expression in cortical actin cytoskeleton
Human Disease Associations: skin disease
Source: Fig. 7 H
Article: XB-ART-55821, PubMed