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XB-PHENO-24223

Xla Wt + dsp CRISPR2, Bharathan NK and Dickinson AJG (2019)

Experiment + Assay: Xla Wt + dsp CRISPR2 + NF29/30-31 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR dsp (Xla) dsp (Xla)
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 29 and 30 to NF stage 31 Krt5.2 Ab1
immunohistochemistry NF stage 29 and 30 to NF stage 31 Ctnnb1 Ab12
Anatomical Phenotypes: abnormal epidermis morphology
Expression Phenotypes (1):
mislocalised krt61L expression in epidermis
Human Disease Associations: skin disease
Source: Fig. S 6 E E' E"
Article: XB-ART-55821, PubMed