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XB-PHENO-24744

Xtr Wt + ift172 CRISPR, Getwan M et al. (2021)

Experiment + Assay: Xtr Wt + ift172 CRISPR + NF62-63 (Other Detection Assay)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR ift172 gRNA1 ift172
 NF stage 2 (2-cell) left blastomere
Conditions:
Assay Type Assay Stages Antibody
Other Detection Assay NF stage 62 to NF stage 63  
Anatomical Phenotypes: abnormal forelimb digit morphology, abnormal hindlimb digit morphology, abnormally increased number of digit, decreased length of forelimb, decreased length of hindlimb, decreased length of hindlimb digit, decreased size of the forelimb digit
Human Disease Associations: kidney disease, ciliopathy, polydactyly
Source: Fig. 1 C bottom, Sup. Fig. 1 g
Article: XB-ART-58465, PubMed