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XB-PHENO-26959

Xtr Wt + acbd6 CRISPR (68), Kaiyrzhanov R et al. (2024)

Experiment + Assay: Xtr Wt + acbd6 CRISPR (68) + NF46-47 (whole-mount microscopy)
Background: Xtr.Nigerian1EXRC
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR acbd6 gRNA1 acbd6
 NF stage 1 whole organism
Conditions:
Assay Type Assay Stages Antibody
whole-mount microscopy NF stage 46 to NF stage 47  
Anatomical Phenotypes: abnormal brain morphology, abnormal chondrocranium, abnormal craniofacial region, abnormal eye morphology, abnormal pharyngeal region, absent eye, decreased size of the head
Human Disease Associations: microcephaly, microphthalmia
Source: Supl. Fig 17 C
Article: XB-ART-60415, PubMed