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XB-PHENO-27250

Xtr Wt + dyrk1a CRISPR, McCluskey KE et al. (2025)

Experiment + Assay: Xtr Wt + dyrk1a CRISPR + NF40 (in situ hybridization)
Background: Xtr.Nigerian1EXRC
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR dyrk1a gRNA1 dyrk1a
 NF stage 1 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 40  
Anatomical Phenotypes: abnormal cell migration in neural crest, abnormally localised neural progenitor cell
Expression Phenotypes (1):
mislocalised phox2b expression in migratory neural crest cell
Human Disease Associations: autism spectrum disorder
Source: Fig. 2c r2c3, 2d
Article: XB-ART-61275, PubMed