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Figure 7. Proposed model for ssDNA oligo action. ssDNA oligos generated by MRN-dependent processing of DSBs stimulates ATM activity by forming MRN–DNA oligo complexes. Elimination of ssDNA oligos by single-stranded DNA exonucleases such as Trex1 (see Discussion) might indirectly control ATM activity.

Image published in: Jazayeri A et al. (2008)

Copyright © 2008, European Molecular Biology Organization. Creative Commons Attribution-NonCommercial-NoDerivatives license

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