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Figure 3. Nudt16 and Syndesmos are closely related members of a gene family. (A) Alignment of a portion of the Syndesmos protein from 17 organisms (denoted by yellow box on right edge) and the corresponding region of Nudt16 from 10 organisms (marked with the blue box on right edge). All Syndesmos orthologs have a repeated glycine/leucine sequence (orange box) in place of the glutamic acid residues (heavy red box) required for catalysis in the NUDIX domain (red box). The green box is the conserved region in Nudt16 proteins, equivalent to the green box in Figure 1. Syndesmos paralogs have all three conserved regions but lack a functional NUDIX domain. The central parts of the proteins are aligned here. The accession numbers are in Supplementary Table 1. (B) Genomic organization of the orthologs in human. Dashed boxes indicate the transcription unit, solid boxes are exons, horizontal lines are introns and the conserved domains are color coded as per Figure 1. Note Nudt16 has a longer 5′-UTR and 3′-UTR than Syndesmos.

Image published in: Taylor MJ and Peculis BA (2008)

© 2008 The Author(s). Creative Commons Attribution-NonCommercial license

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