XB-LINE-2369
Line Name: Xtr.Tg(hhex:trTA;TRE:ΔLL-Cdh1-GFP)Zorn
| Summary |
|
| Synonym: |
Cdh1 mutant (ΔLL-Cdh1) |
| Species: |
Xenopus tropicalis |
| Background Strain: |
Xtr.NigerianSt549NXR
|
| Description: |
Custom inducible Tg/mutant line generated by the Zorn Lab. The bipartite transgene Tg(hhex:trTA;TRE:ΔLL-Cdh1-GFP) specifically expresses the mutant ΔLL-Cdh1 or a control wild-type (WT)-Cdh1 in the foregut, upon administration of doxycycline (DOX). |
| Phenotype Description: |
compared with non-induced and WT-Cdh1 controls, ~ 70% of ΔLL-Cdh1 transgenic embryos may exhibit tracheo-oesophageal fistula phenotype, with a significantly longer segment of the TE septum forming an unseparated epithelial bilayer. |
| Color Morph: |
pigmented |
| Breeding Type: |
UNKNOWN
|
| Lab of Origin: |
Zorn |
| Line Type: |
Mutant, Transgenic |
| Mutated Gene(s): |
cdh1
|
| MTA Required: |
No
|
| Public: |
Yes
|
| Anatomical Phenotypes: |
cdh1 |
| Disease Phenotypes: |
cdh1 |
|
Cdh1 immunostaining and confocal microscopy of trachea/oesophagus in a NF44 stage transgenic Xtr.Tg(hhex:trTA;TRE:ΔLL-Cdh1-GFP){Zorn} embryo, showing TEF (tracheal-eosophogeal fistula) phenotype.
|
| Stock Center |
RRID |
Generation |
DOB |
# Males |
# Females |
Availability |
Mutant Details |
|
No availability, contact the Lab of Origin for information about this Xenopus line or strain. Articles using these frogs are listed on the Attribution Tab.
|
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